ESR 4: Protein-RNA docking

Protein-RNA docking

Project: Improve methods to dock RNA with proteins.

This project focuses on the following aspects:
1. Optimize algorithms for single-stranded RNA docking methodology, based on our previous works
2. Create a RNA-RRM model generation pipeline
3. Incorporate new sources of information for data-driven docking: multiple conformations, low resolution biophysical data, conserved amino-acid – nucleotide contacts
4. Assist with developing a framework of protein design for RRMs

This project involves a six-month secondment at Dynamic Biosensors GmbH (Germany) to relate in silico work to the experimental determination of RNA-RRM binding with biochips, and to learn about commercial software development.


H2020-MSCA-ITN-2018 813239 (Jan. 1, 19-Dec. 31, 23)
RNAct - Enabling proteins with RNA recognition motifs for synthetic biology and bio-analytics