RNAct ESR7 project

RRM dynamics

Project: Analyse the dynamics of RRMs via structural biology (NMR) and biophysical techniques.

In this project, the PhD student will experimentally study RRMs using a range of biophysical and structural biology techniques, in order to fully characterize and understand their binding with RNA at the atomic level. The ESR will focus on multi-domain RRMs, their interaction with RNA and the role of the linker on their orientation, using solution NMR with also paramagnetic probes.

This project involves a three-month secondment at CNRS (CR CNRS, LORIA), to learn about computational techniques for RNA/RRM interactions and how to apply them with the experimental structural biology data.