Project: Improve methods to dock RNA with proteins.
This project focuses on the following aspects:
1. Optimize algorithms for single-stranded RNA docking methodology, based on our previous works
2. Create a RNA-RRM model generation pipeline
3. Incorporate new sources of information for data-driven docking: multiple conformations, low resolution biophysical data, conserved amino-acid – nucleotide contacts
4. Assist with developing a framework of protein design for RRMs
This project involves a six-month secondment at Dynamic Biosensors GmbH (Germany) to relate in silico work to the experimental determination of RNA-RRM binding with biochips, and to learn about commercial software development.