Project: Calculate RRM structures, and help to design new RRMs in conjunction with computational and experimental ESRs in the project.
This project will design RRM proteins with novel RNA binding properties and develop small molecules to modulate RNA binding activity. The design will be confirmed using experimental structural biology. The modulation of RNA binding by small molecules will be experimentally assessed by combining state-of-the-art solution NMR and biophysical techniques (ITC, FP, SPR). The project is in collaboration with computational groups of the ITN for the design of RRM variants and for experimental validation in cellular assays.