RRM design

Ph.D. job offer: Calculate RRM structures, and help to design new RRMs in conjunction with computational and experimental ESRs in the project.

ESR 5: RRM design

This project will design RRM proteins with novel RNA binding properties and develop small molecules to modulate RNA binding activity. The design will be confirmed using experimental structural biology. The modulation of RNA binding by small molecules will be experimentally assessed by combining state-of-the-art solution NMR and biophysical techniques (ITC, FP, SPR). The project is in collaboration with computational groups of the ITN for the design of RRM variants and for experimental validation in cellular assays.

More detailed information available here.

Funding

H2020-MSCA-ITN-2018 813239 (Jan. 1, 19-Dec. 31, 23)
RNAct - Enabling proteins with RNA recognition motifs for synthetic biology and bio-analytics