RRM dynamics

Ph.D. job offer: Analyse the dynamics of RRMs via structural biology (NMR) and biophysical techniques.

ESR 7: RRM dynamics

The PhD student will experimentally study RRMs using a range of biophysical and structural biology techniques, in order to fully characterize and understand their binding with RNA at the atomic level. The ESR will focus on multi-domain RRMs, their interaction with RNA and the role of the linker on their orientation, using solution NMR with also paramagnetic probes.

The PhD will do a 3 months secondment at CNRS (CR CNRS, LORIA), to learn about computational techniques for RNA/RRM interactions and how to apply them with the experimental structural biology data.

The PhD will attend the international PhD school in Structural Biology at CERM (University of Florence). The International Doctorate in Structural Biology is an international doctorate in collaboration with the Universities of Frankfurt and Utrecht.

Keywords: molecular biology, protein expression, structural biology, drug design, multi domain protein dynamics, NMR, paramagnetic NMR, protein-RNA interaction

Eligibility: Candidates must have a master degree in any of the relevant disciplines: chemistry, structural biology, biochemistry, medicinal chemistry. The project is highly interdisciplinary and combines molecular biology and recombinant protein expression with advanced techniques in structural biology focusing on solution and solid-state NMR. Some experimental experience in these techniques is very desirable. Candidates must be highly motivated and interested in interdisciplinary research and developing new ideas.

Candidates must be fluent in English.

More detailed information available here.

Funding

H2020-MSCA-ITN-2018 813239 (Jan. 1, 19-Dec. 31, 23)
RNAct - Enabling proteins with RNA recognition motifs for synthetic biology and bio-analytics