RRM-RNA biochip

Ph.D. job offer: Create biochips to study RRM/RNA interactions.

ESR 9: RRM-RNA biochip

A PhD candidate will be recruited at Dynamic Biosensors in Munich for the development and optimization of RNA bio-chips. Aim is the on-chip immobilization of RNA recognition motifs (RRM) for interaction analysis with RNA-binding proteins. These experiments will provide detailed insights into the allosteric modulation of RRM-protein interactions and will additionally provide information on the size and conformation of the protein-RNA complexes.

The experimental data will provide the constraints for structure based-based modelling of RRM-protein interactions. For training in structure-based modelling approaches you will spend four months at CNRS (Paris, France). Furthermore, you will get the opportunity to connect to several research groups inside and outside EU, including pharma companies, through other projects developed in partnership with DBS. You will be part of an interdisciplinary R & D Team. A broad basis for understanding DNA based biochemistry is required. Knowledge in molecular interaction analysis methods is a plus.

Skills / Qualification

More detailed information available here.

Funding

H2020-MSCA-ITN-2018 813239 (Jan. 1, 19-Dec. 31, 23)
RNAct - Enabling proteins with RNA recognition motifs for synthetic biology and bio-analytics